Mechanism of Blood Clotting

10.4

Mechanism of Blood Clotting

Importance of the mechanism of blood clotting:

Mechanism of blood clotting:

Mechanism of blood clotting

Platelet in contact with fibres exposed to the damaged blood vessel

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Platelet will clump at the site of injury and produce thrombokinase

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Inactive prothrombin converted to active thrombin by thrombokinase

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Thrombin then will convert soluble fibrinogen to insoluble fibrin filament

Fibrin filament forms a sticky network and traps red blood cell

Blood clot is formed

Issues of blood clotting:

Cause diseases such as:

Hemophilia:

A genetic disease that caused by lacking of blood clotting factors.
Translated through sex-linked genes in chromosome X.
Can cause excessive and prolonged blood loss.
treatment: treated through injection of factor VIII or IX and genetic engineering.

Thrombosis:

A disease caused by the blood clot that form in the blood vessels.
The blood clot is known as thrombus.
Can narrow the blood vessels; interrupt the blood flow; can cause heart attack.
If the blood clot prevent the blood flow in the brain, it can cause stroke and paralyse.
Treatment: treated with aspirin, hrparin or warfarin.

Embolism: